Melatonin promotes longevity through multiple, synergistic mechanisms that target the hallmarks of aging (genomic instability, telomere attrition, epigenetic drift, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and disabled macroautophagy). Below is a structured, evidence-based overview of its anti-aging actions, lifespan data, and translational implications 1. Core […]
The sun’s effect on the retina in the morning or daytime does not directly stimulate melatonin secretion—instead, it strongly suppresses it. However, this morning light exposure is essential for regulating the timing and amplitude of nighttime melatonin secretion later that day. Here’s how it works. Morning Sunlight Resets the Circadian Clock (Phase Advance) Mechanism: Bright […]
Normal melatonin secretion in humans is primarily regulated by the suprachiasmatic nucleus (SCN) in the hypothalamus, which acts as the body’s master circadian clock. Melatonin is produced by the pineal gland in response to signals from the SCN via the sympathetic nervous system. The key stimulus for its release is darkness, with secretion typically beginning […]
Potential risks associated with long-term melatonin use among adults with chronic insomnia were highlighted in a recent preliminary study presented at the American Heart Association’s Scientific Sessions 2025 Led by Dr. Ekenedilichukwu Nnadi, a chief resident at SUNY Downstate Health Sciences University, the observational analysis examined over 130,000 patients, half of whom had documented chronic […]
Sleep involves a complex interplay of physiological processes that restore and regulate the body, orchestrated by the brain and influenced by hormones like melatonin. Below, I’ll outline the key body processes during sleep, the role of melatonin, and address whether organs are “updated” at specific times. Our Body Processes During Sleep Sleep is divided into […]