What are Short-Chain Fatty Acids (SCFAs) and what role do they play in our overall health? They play an enormous role in our health, encompassing gut health, metabolism, immunity, cardiovascular health, musculoskeletal health, neurological health, and mental health and wellbeing. Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, are produced by our gut microbiota […]
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, exhibit broad therapeutic potential across multiple disease categories, including neurodegenerative and demyelinating conditions. They primarily act through mechanisms like G-protein-coupled receptor (GPCR) activation (e.g., GPR41/43/109A), histone deacetylase (HDAC) inhibition, anti-inflammatory effects (e.g., Treg promotion, NF-κB suppression), and metabolic regulation (e.g., AMPK activation for lipid/glucose homeostasis). […]
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Alzheimer’s disease (AD). Short-chain fatty acids are produced by gut microbiota fermentation of dietary fibers. These SCFAs play a complex role in Alzheimer’s disease (AD) through the microbiota-gut-brain axis. AD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium […]
Gut dysbiosis, marked by diminished microbial diversity and imbalanced bacterial composition, is a hallmark of Alzheimer’s disease (AD) AD often emerges in prodromal stages like mild cognitive impairment (MCI) and contributes to pathogenesis through the microbiota-gut-brain axis. AD patients show consistent reductions in short-chain fatty acid (SCFA)-producing taxa and enrichments in pro-inflammatory genera, correlating with […]
Gut dysbiosis is characterized by reduced microbial diversity and shifts in bacterial composition. It is a prominent feature in Parkinson’s disease (PD), often preceding motor symptoms by years and contributing to disease initiation and progression via the microbiota-gut-brain axis. PD patients exhibit consistent alterations, including depletion of short-chain fatty acid (SCFA)-producing bacteria and enrichment of […]
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Parkinson’s disease (PD). They target the gut-brain axis, mitigating alpha-synuclein (α-syn) pathology, reducing neuroinflammation, and enhancing dopaminergic function. PD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium prausnitzii, Roseburia spp.) and lower fecal/plasma SCFA levels, correlating with motor […]
Breast Cancer Risk Factors and Recent Developments According to a September 22, 2025 CDC post, breast cancer risk factors are divided into modifiable and non-modifiable categories: Modifiable: Increasing physical activity, reducing alcohol consumption, limiting hormone intake, and maintaining a healthy weight. Non-modifiable: Genetic mutations, dense breast tissue, family history of breast or ovarian cancer, and […]
Nonalcoholic fatty liver disease (NAFLD) is a common condition where excess fat builds up in the liver, often linked to obesity, diabetes, and metabolic issues. While lifestyle changes like diet and exercise are the primary management strategies, some natural plant-based treatments have shown promise in clinical studies for reducing liver fat, inflammation, and related markers. […]
Gut microbiome testing can provide insights into the composition and diversity of microorganisms in our gastrointestinal tract. This may be particularly relevant in people with Candida overgrowth, leaky gut, acid reflux (GERD), long-term PPI use (Prilosec), and a history of corticosteroids, antibiotics, and thyroid medication (Synthroid). Let us address the role of gut microbiome testing […]
Let us look at using apple cider vinegar to increase stomach acid and reduce Candida for a client case with Candida overgrowth, leaky gut and long-term PPI, corticosteroid, antibiotic, and thyroid medication use. Should our client try 1 tablespoon of apple cider vinegar (ACV) diluted in 8 ounces of water after meals as a potential […]
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