HORMESIS – The Anti-Fragile Principle of Biology “What doesn’t kill you makes your mitochondria stronger.” 1. HORMESIS DEFINED Hormesis = a biphasic dose-response where low-dose stress triggers adaptive, protective responses that improve resilience, while high-dose stress causes damage. Classic Hormetic Curve Benefit ↑ | ↗↗↗↗↗ (Adaptive Zone) | ↗↗ | ↗↗ |↗↗ +—————-→ Stress Dose […]
Melatonin promotes longevity through multiple, synergistic mechanisms that target the hallmarks of aging (genomic instability, telomere attrition, epigenetic drift, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and disabled macroautophagy). Below is a structured, evidence-based overview of its anti-aging actions, lifespan data, and translational implications 1. Core […]
To cultivate the most beneficial gut bacteria, such as Akkermansia muciniphila, Bifidobacterium species, Lactobacillus species, and others linked to health and longevity (e.g., Faecalibacterium prausnitzii), focus on evidence-based dietary, lifestyle, and environmental strategies. These bacteria support gut barrier function, reduce inflammation, produce short-chain fatty acids (SCFAs) like butyrate, and enhance overall health, as seen in […]
Centenarians, people aged 100 or older, often share these characteristics based on research and observations: Genetics: Strong genetic factors are present, with many individuals having family members who lived long lives. Lifestyle: Healthy diet, often plant-based with moderate portions (e.g., Mediterranean or Okinawan diets). Regular, low-intensity physical activity, such as walking or gardening. Limited smoking […]
Based on animal and in vitro studies, nanoplastics (plastic particles <1 μm) can disrupt the gut microbiome, potentially impacting health. Here’s how: Dysbiosis: Nanoplastics alter microbial composition, often reducing beneficial bacteria like Bifidobacterium and Lactobacillus (key for short-chain fatty acid production and gut barrier health) while increasing opportunistic pathogens like Proteobacteria or Firmicutes. For example, […]
Toxic loads in our modern US society refer to the cumulative exposure to environmental pollutants, chemicals, and toxins that can hurt health. Several differences in toxic exposure emerge when comparing the United States to Blue Zones, regions such as Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; Ikaria, Greece; and Loma Linda, California, which are known […]
An overview of nutritional frameworks that align with the goals of health, longevity, and disease prevention. These frameworks offer distinct approaches to nutrition, ranging from evidence-based dietary patterns to integrative and plant-based systems. I’ll summarize each framework’s core principles, key foods, structure, and how it compares to Dr. William Li’s 5x5x5 framework, Dr. Jingduan Yang’s […]