Synbiotics are combinations of probiotics (live beneficial bacteria) and prebiotics (non-digestible fibers that feed them), designed to synergistically improve gut health. They enhance SCFA production—primarily acetate, propionate, and butyrate—more effectively than probiotics or prebiotics alone by providing both the microbes and their preferred substrates for fermentation in the colon. This synergistic combination boosts microbial diversity, […]
You may wonder what the dietary sources of short-chain fatty acids (SCFAs) are, since they are so important in promoting overall health and longevity. Short-chain fatty acids (SCFAs)—primarily acetate, propionate, and butyrate—are mostly produced endogenously by gut bacteria through the process of dietary fiber fermentation. However, small amounts are available directly from certain foods. Direct […]
What are Short-Chain Fatty Acids (SCFAs) and what role do they play in our overall health? They play an enormous role in our health, encompassing gut health, metabolism, immunity, cardiovascular health, musculoskeletal health, neurological health, and mental health and wellbeing. Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, are produced by our gut microbiota […]
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, exhibit broad therapeutic potential across multiple disease categories, including neurodegenerative and demyelinating conditions. They primarily act through mechanisms like G-protein-coupled receptor (GPCR) activation (e.g., GPR41/43/109A), histone deacetylase (HDAC) inhibition, anti-inflammatory effects (e.g., Treg promotion, NF-κB suppression), and metabolic regulation (e.g., AMPK activation for lipid/glucose homeostasis). […]
Knowing the sources of dietary fibers that the Gut Microbiome ferments into short-chain fatty acids (SCFAs) can change your life and health. Our gut bacteria produce short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, through the fermentation of non-digestible carbohydrates, including soluble and fermentable dietary fibers. These fibers are found in various plant-based […]
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Alzheimer’s disease (AD). Short-chain fatty acids are produced by gut microbiota fermentation of dietary fibers. These SCFAs play a complex role in Alzheimer’s disease (AD) through the microbiota-gut-brain axis. AD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium […]
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Parkinson’s disease (PD). They target the gut-brain axis, mitigating alpha-synuclein (α-syn) pathology, reducing neuroinflammation, and enhancing dopaminergic function. PD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium prausnitzii, Roseburia spp.) and lower fecal/plasma SCFA levels, correlating with motor […]