Gut dysbiosis is characterized by reduced microbial diversity and shifts in bacterial composition. It is a prominent feature in Parkinson’s disease (PD), often preceding motor symptoms by years and contributing to disease initiation and progression via the microbiota-gut-brain axis. PD patients exhibit consistent alterations, including depletion of short-chain fatty acid (SCFA)-producing bacteria and enrichment of […]
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Parkinson’s disease (PD). They target the gut-brain axis, mitigating alpha-synuclein (α-syn) pathology, reducing neuroinflammation, and enhancing dopaminergic function. PD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium prausnitzii, Roseburia spp.) and lower fecal/plasma SCFA levels, correlating with motor […]
Dementia: Pathways to Prevention Dementia, a progressive decline in cognitive function that affects memory, thinking, and daily activities, is a growing global concern. While there is no cure, emerging research offers strong evidence that a significant portion—up to 45%—of dementia cases could potentially be prevented or delayed through lifestyle modifications targeting modifiable risk factors. thelancet.com […]
We have examined the gut microbiota, blood-brain barrier (BBB), gut-brain axis, and probiotics in previous articles in relation to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Let us look at a detailed overview of vagus nerve stimulation (VNS), focusing on its mechanisms, applications, recent research (2020–2025), and connections to the BBB, microbiota, and gut-brain axis. […]
Probiotics are proven to slow down the progression of Parkinson’s disease (PD) and alleviate symptoms. Let’s examine the relationship between the gut microbiota, the blood-brain barrier (BBB), the gut-brain axis, and the vagus nerve in Parkinson’s disease, with a focus on its mechanisms, recent research (2020–2025), and connections to the blood-brain barrier (BBB) and vagus […]