Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, emerge as promising therapeutic agents in Alzheimer’s disease (AD). Short-chain fatty acids are produced by gut microbiota fermentation of dietary fibers. These SCFAs play a complex role in Alzheimer’s disease (AD) through the microbiota-gut-brain axis. AD patients exhibit gut dysbiosis with reduced SCFA-producing bacteria (e.g., Faecalibacterium […]
Gut dysbiosis, marked by diminished microbial diversity and imbalanced bacterial composition, is a hallmark of Alzheimer’s disease (AD) AD often emerges in prodromal stages like mild cognitive impairment (MCI) and contributes to pathogenesis through the microbiota-gut-brain axis. AD patients show consistent reductions in short-chain fatty acid (SCFA)-producing taxa and enrichments in pro-inflammatory genera, correlating with […]
Dementia: Pathways to Prevention Dementia, a progressive decline in cognitive function that affects memory, thinking, and daily activities, is a growing global concern. While there is no cure, emerging research offers strong evidence that a significant portion—up to 45%—of dementia cases could potentially be prevented or delayed through lifestyle modifications targeting modifiable risk factors. thelancet.com […]
We have examined the gut microbiota, blood-brain barrier (BBB), gut-brain axis, and probiotics in previous articles in relation to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Let us look at a detailed overview of vagus nerve stimulation (VNS), focusing on its mechanisms, applications, recent research (2020–2025), and connections to the BBB, microbiota, and gut-brain axis. […]
This is an overview of probiotics for Alzheimer’s disease (AD), focusing on their mechanisms, recent research (2020–2025), and connections to the BBB (Blood-Brain Barrier) and vagus nerve. Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits, including potential neuroprotective effects in Alzheimer’s disease (AD). This article integrates insights and relevant findings, […]